PEPTIDE CHEMISTRY

Members Fields of Research

Members

Kristin Jauch (KJ)(kristin.jauch@uni-tuebingen.de)	Gottfried Panhaus (GP)	Nils Clausen (NC)(nils.clausen@uni-tuebingen.de)

Dr. Bernd Henkel (BH)

• Optimisation of solid phase synthesis of "difficult sequences" (K ⁺ - ion channel segments, HIV - protease) by means of
  • solvent mixtures and additives (" magic mixture ")
  • elevated temperature
  • temporary backbone protection (N ^a -Tmob)
  • coupling reagents (KJ, BH, NC, GP)

• Fragment condensation in solution (BH) and on solid phase (NC)

• Development of linkers for solid phase synthesis and fragment condensation (BH)

• Solid phase synthesis of human insulin A- and B-chain (GP)

• "Inverse" direction Solid Phase Peptide Synthesis (BH, NC)

• 2-NitroFmoc - a new protecting group for amines and amino acids (BH)

Index

Index General Information Analytics Oligonucleotides Conversion Polymeres Sidelines